To gain insight into the genetic link between aging and disease, we identify functional genetic variation in human populations and assess their potential functional impact on aging and disease. We take an integrated approach to study the connection between disease and aging at different levels, i.e., from genetic determinants in the form of genetic variants, through cell type- and tissue-specific regulated gene expression, to molecular and cellular endpoints in the tissues, leading to new targets for interventions as well as genetic markers for aging and its associated diseases.

In addition, since the female reproductive system is the first to age in the human body, we are leveraging our expertise in human genetics, functional genomics, molecular and cellular biology, and stem cell engineering to address key unanswered questions on reproductive aging in women.