Publications

  • • Zhu Y, Rosenfeld MG, Suh Y. Ultrafine mapping of chromosome conformation at hundred basepair resolution reveals regulatory genome architecture. Proc Natl Acad Sci U S A. 2023 Nov 7;120(45):e2313285120. doi: 10.1073/pnas.2313285120. Epub 2023 Nov 3. PMID: 37922325; PMCID: PMC10636305.

    • Albert O, Sun S, Huttner A, Zhang Z, Suh Y, Campisi J, Vijg J, Montagna C. Chromosome instability and aneuploidy in the mammalian brain. Chromosome Res. 2023 Nov 1;31(4):32. doi: 10.1007/s10577-023-09740-w. PMID: 37910282.

    • Bravo JI, Mizrahi CR, Kim S, Zhang L, Suh Y, Benayoun BA. An eQTL-based Approach Reveals Candidate L1 Transcriptional Regulators in Lymphoblastoid Cells. bioRxiv [Preprint]. 2023 Sep 7:2023.08.15.553416. doi: 10.1101/2023.08.15.553416. PMID: 37645920; PMCID: PMC10461994.

    • Zhu Y, Ryu S, Tare A, Barzilai N, Atzmon G, Suh Y. Targeted sequencing of the 9p21.3 region reveals association with reduced disease risks in Ashkenazi Jewish centenarians. Aging Cell. 2023 Oct;22(10):e13962. doi: 10.1111/acel.13962. Epub 2023 Aug 22. PMID: 37605876; PMCID: PMC10577543.

    • Zhu Y, Tazearslan C, Rosenfeld MG, Fiser A, Suh Y. Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of p16INK4a. Aging Cell. 2023 Sep;22(9):e13908. doi: 10.1111/acel.13908. Epub 2023 Jun 22. PMID: 37345431; PMCID: PMC10497822.

    • Wang X, Jung HJ, Milholland B, Cui J, Tazearslan C, Atzmon G, Wang X, Yang J, Guo Q, Barzilai N, Robbins PD, Suh Y. The regulation of Insulin/IGF-1 signaling by miR-142-3p associated with human longevity. bioRxiv [Preprint]. 2023 May 20:2023.05.19.541542. doi: 10.1101/2023.05.19.541542. PMID: 37292828; PMCID: PMC10245758.

    • Kaeberlein TL, Green AS, Haddad G, Hudson J, Isman A, Nyquist A, Rosen BS, Suh Y, Zalzala S, Zhang X, Blagosklonny MV, An JY, Kaeberlein M. Evaluation of off-label rapamycin use to promote healthspan in 333 adults. Geroscience. 2023 Oct;45(5):2757-2768. doi: 10.1007/s11357-023-00818-1. Epub 2023 May 16. PMID: 37191826; PMCID: PMC10187519.

    • Vijg J, Schumacher B, Abakir A, Antonov M, Bradley C, Cagan A, Church G, Gladyshev VN, Gorbunova V, Maslov AY, Reik W, Sharifi S, Suh Y, Walsh K. Mitigating age-related somatic mutation burden. Trends Mol Med. 2023 Jul;29(7):530-540. doi: 10.1016/j.molmed.2023.04.002. Epub 2023 Apr 29. PMID: 37121869.

    • Shi M, Han W, Loudig O, Shah CD, Dobkin JB, Keller S, Sadoughi A, Zhu C, Siegel RE, Fernandez MK, DeLaRosa L, Patel D, Desai A, Siddiqui T, Gombar S, Suh Y, Wang T, Hosgood HD, Pradhan K, Ye K, Spivack SD. Initial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination. Sci Rep. 2023 Apr 24;13(1):6620. doi: 10.1038/s41598-023-33698-8. PMID: 37095155; PMCID: PMC10126132.

    • Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen SL, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad SA, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia BA, Robbins PD, Vijg J, Seluanov A, Suh Y, Gorbunova V. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. EMBO J. 2023 Feb 1;42(3):e113326. doi: 10.15252/embj.2022113326. Erratum for: EMBO J. 2022 Nov 2;41(21):e110393. PMID: 36722290; PMCID: PMC9890223.

    • Gonzalez B, Tare A, Ryu S, Johnson SC, Atzmon G, Barzilai N, Kaeberlein M, Suh Y. High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity. Geroscience. 2023 Feb;45(1):311-330. doi: 10.1007/s11357-022-00634-z. Epub 2022 Aug 10. PMID: 35948858; PMCID: PMC9886794.

    • SenNet Consortium (2022). NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. Nature Aging, 2(12), 1090-1100. doi: 10.1038/s43587-022-00326-5. PMID: 36936385; PMCID: PMC10019484

    • Strong, R., Miller, R. A., Cheng, C. J., Nelson, J. F., Gelfond, J., Allani, S. K., Diaz, V., Dorigatti, A. O., Dorigatti, J., Fernandez, E., Galecki, A., Ginsburg, B., Hamilton, K. L., Javors, M. A., Kornfeld, K., Kaeberlein, M., Kumar, S., Lombard, D. B., Lopez‐Cruzan, M., Miller, B. F., Rabinovitch, P., Reifsnyder, P., Rosenthal, N. A., Bogue, M. A., Salmon, A. B., Suh, Y., Verdin, E., Weissbach, H., Newman, J., Maccchiarini, F., & Harrison, D. E. (2022). Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice. Aging cell, e13724.

    • Simon, M., Yang, J., Gigas, J., Earley, E. J., Hillpot, E., Zhang, L., Zagorulya, M., Tombline, G., Gilbert, M., Yuen, SL., Pope. A., Van Meter, M., Emmrich, S., Firsanov, D., Athreya, A., Biashad, SA., Han, J., Ryu, S., Tare, A., Zhu, Y., Hudgins, A., Atzmon, G., Barzilai, N., Wolfe, A., Moody, K., Garcia, BA., Thomas, DD., Robbins, PD., Vijg, J., Seluanov, A., Suh, Y., & Gorbunova, V. (2022). A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. The EMBO Journal, 41(21), e110393.

    • Gonzalez, B., Tare, A., Ryu, S., Johnson, S. C., Atzmon, G., Barzilai, N., Kaeberlein, M. & Suh, Y. (2022). High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity. GeroScience, 1-20.

    • Hudgins, A. D., Zhou, S., Arey, R. N., Murphy, C. T., & Suh, Y. (2022). A systems biology-based identification and in vivo functional screening of Alzheimer's disease risk genes reveals modulators of memory function. bioRxiv, 2022-08.

    • Miller, E. C., Wilczek, A., Bello, N. A., Tom, S., Wapner, R., & Suh, Y. (2022). Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics. Ageing research reviews, 73, 101535. https://doi.org/10.1016/j.arr.2021.101535

    • Meron, E., Thaysen, M., Angeli, S., Antebi, A., Barzilai, N., Baur, J. A., Bekker-Jensen, S., Birkisdottir, M., Bischof, E., Bruening, J., Brunet, A., Buchwalter, A., Cabreiro, F., Cai, S., Chen, B., Ermolaeva, M., Ewald, C., Ferrucci, L., Florian, M., Fortney, K., Freund, A., Georgievskaya, A., Gladyshev, V., Glass, D., Golato, T., Gorbunova, V., Hoejimakers, J., Houtkooper, R., Jager, S., Jaksch, F., Janssens, G., Jensen, M., Kaeberlein, M., Karsenty, G., Keizer, P., Kennedy, B., Kirkland, J., Kjaer, M., Kroemer, G., Lee, K., Lemaitre, J., Liaskos, D., Longo, V., Lu, Y., MacArthur, M., Maier, A. Manakanatas, C., Mitchell, S., Moskalev, A., Niedernhofer, L., Ozerov, I., Partridge, L., Passegue, E., Petr, M., Peyer, J., Radenkovic, D., Rando, T., Rattan, S., Riedel, C., Rudolph, L., Ai, R., Serrano, M., Schumacher, B., Sinclair, D., Smith, R., Suh, Y. Taub, P., Trapp, A., Trendelenburg, A., Valenzano, D., Verburgh, K., Verdin, E., Vijg, J., Westendorp, R., Zonari, A., Bakula, D., Zhavoronkov, A., & Scheibye-Knudsen, M. (2022). Meeting Report: Aging Research and Drug Discovery. Aging (Albany NY), 14(2), 530.

    • Kim, S. S., Hudgins, A. D., Gonzalez, B., Milman, S., Barzilai, N., Vijg, J., Tu, Z., & Suh, Y. (2021). A Compendium of Age-Related PheWAS and GWAS Traits for Human Genetic Association Studies, Their Networks and Genetic Correlations. Frontiers in genetics, 12, 680560. https://doi.org/10.3389/fgene.2021.680560

    • Zhang, L., Zhao, J., Mu, X., McGowan, S. J., Angelini, L., O'Kelly, R. D., Yousefzadeh, M. J., Sakamoto, A., Aversa, Z., LeBrasseur, N. K., Suh, Y., Huard, J., Kamenecka, T. M., Niedernhofer, L. J., & Robbins, P. D. (2021). Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging. Aging cell, 20(12), e13486. https://doi.org/10.1111/acel.13486

    • Kim, S. S., Hudgins, A. D., Yang, J., Zhu, Y., Tu, Z., Rosenfeld, M. G., DiLorenzo, T. P., & Suh, Y. (2021). A comprehensive integrated post-GWAS analysis of Type 1 diabetes reveals enhancer-based immune dysregulation. PloS one, 16(9), e0257265. https://doi.org/10.1371/journal.pone.0257265

    • Wei, S., Kohl, E., Djandji, A., Morgan, S., Whittier, S., Mansukhani, M., Hod, E., D'Alton, M., Suh, Y., & Williams, Z. (2021). Direct diagnostic testing of SARS-CoV-2 without the need for prior RNA extraction. Scientific reports, 11(1), 2402. https://doi.org/10.1038/s41598-021-81487-y

    • Ryu, S., Han, J., Norden-Krichmar, T. M., Zhang, Q., Lee, S., Zhang, Z., Atzmon, G., Niedernhofer, L. J., Robbins, P. D., Barzilai, N., Schork, N. J., & Suh, Y. (2021). Genetic signature of human longevity in PKC and NF-κB signaling. Aging cell, 20(7), e13362. https://doi.org/10.1111/acel.13362

    • Dong, X., Sun, S., Zhang, L., Kim, S., Tu, Z., Montagna, C., Maslov, A. Y., Suh, Y., Wang, T., Campisi, J., & Vijg, J. (2021). Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions. Aging cell, 20(6), e13357. https://doi.org/10.1111/acel.13357

    • Wei, S., Suryawanshi, H., Djandji, A., Kohl, E., Morgan, S., Hod, E. A., Whittier, S., Roth, K., Yeh, R., Alejaldre, J. C., Fleck, E., Ferrara, S., Hercz, D., Andrews, D., Lee, L., Hendershot, K. A., Goldstein, J., b, Mansukhani, M., & Williams, Z. (2021). Field-deployable, rapid diagnostic testing of saliva for SARS-CoV-2. Scientific reports, 11(1), 5448. https://doi.org/10.1038/s41598-021-84792-8

    • Zeng, L., Peng, S., Kim, S., Zhu, J., Zhang, B., Suh, Y., & Tu, Z. (2021). A joint analysis of longevity and age-related disease variants for gene expression association. bioRxiv.

    • Gorbunova, V., Suh, Y., Simon, M., Trombline, G., Yang, J., Earley, E. J., Schaff, T. M., Zhang, L., Zagorulya, M., Tombline, G., Gilbert, M., Yuen, S., Pope, A., Meter, M. V., Emmrich, S., Han, Jeehae., Ryu, S., Tare, A., Zhu, Y., Hudgins, A., Atzmon, G., Barzilai, N., Wolfe, A., Moody, K., Garcia, B., Thomas, D., Robbins, P., Vijg, J., Seluanov, A. (2021). A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. bioRxiv.

    • Spivack, S. D., Han, W., Loudig, O., Shah, C., Dobkin, J. B., Keller, S., Zhu, C., Patel, D., Desai, A., Gombar, S., Suh, Y., WAng, T., Hosgood, H.D., Pradhan, K., Ye, K., & Shi, M. (2021). An Exhaled MicroRNA Panel Interrogated for Lung Cancer Case-Control Discrimination. In B8. B008 LUNG CANCER 2021: ADVANCES IN TARGETS, SCREENING, AND DIAGNOSIS (pp. A1077-A1077). American Thoracic Society.

    • Dong, X., Sun, S., Zhang, L., Kim, S., Tu, Z., Montagna, C., Maslov, A., Suh, Y., Wang, T., Campisi, J., & Vijg, J. (2021). Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions. Aging cell, 20(6), e13357.

    • Ryu, S., Han, J., Norden‐Krichmar, T. M., Zhang, Q., Lee, S., Zhang, Z., Atzmon, G., Niedernhofer, L., Robbins, P., Barzilai, N., Schork, N., & Suh, Y. (2021). Genetic signature of human longevity in PKC and NF‐κB signaling. Aging cell, 20(7), e13362.

    • Lin, J. R., Sin-Chan, P., Napolioni, V., Torres, G. G., Mitra, J., Zhang, Q., Jabalameli, M. R., Wang, Z., Nguyen, N., Gao, T., Laudes, M., Görg, S., Franke, A., Nebel, A., Greicius, M., Atzmon, G., Ye, K., Gorbunova, V., Ladiges, W., Schuldiner, A., Niedernhofer, L., Robbins, P., Milman, S., Suh, Y., Vijg, J., Barzilai, N., & Zhang, Z. D. (2021). Rare genetic coding variants associated with human longevity and protection against age-related diseases. Nature Aging, 1(9), 783-794.

    • Wagner, T., Micheletti, R., Taylor, H., Suh, Y., Rosenfeld, M. G., & Zemljic-Harpf, A. E. (2021, September). Abstract MP256: CCCTC-binding Factor Site Mutation In Sirt1 Promoter Reduces Systolic Cardiac Function In Mice. In Circulation Research (Vol. 129, No. Suppl_1, pp. AMP256-AMP256). Hagerstown, MD: Lippincott Williams & Wilkins.

    • Zhang, L., Zhao, J., Mu, X., McGowan, S. J., Angelini, L., O'Kelly, R. D., Yousefzadeh, M. J., Sakamoto, A., Aversa, Z., LeBrasseur, N., Suh, Y., Huard, J., Kamenecka, T. M., Niedernhofer, L. J., & Robbins, P. D. (2021). Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging. Aging cell, 20(12), e13486.

    • Zeng, L., Yang, J., Peng, S., Zhu, J., Zhang, B., Suh, Y., & Tu, Z. (2020). Transcriptome analysis reveals the difference between "healthy" and "common" aging and their connection with age-related diseases. Aging cell, 19(3), e13121. https://doi.org/10.1111/acel.13121

    • Shin, Y. J., Kwon, E. S., Lee, S. M., Kim, S. K., Min, K. W., Lim, J. Y., Lee, B., Kang, J. S., Kwak, J. Y., Son, Y. H., Choi, J. Y., Yang, Y. R., Kim, S., Kim, Y. S., Jang, H. C., Suh, Y., Yoon, J. H., Lee, K. P., & Kwon, K. S. (2020). A subset of microRNAs in the Dlk1-Dio3 cluster regulates age-associated muscle atrophy by targeting Atrogin-1. Journal of cachexia, sarcopenia and muscle, 11(5), 1336–1350. https://doi.org/10.1002/jcsm.12578

    • Yang, J., Peng, S., Zhang, B., Houten, S., Schadt, E., Zhu, J., Suh, Y., & Tu, Z. (2020). Human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases. GeroScience, 42(1), 353–372. https://doi.org/10.1007/s11357-019-00106-x

    • Kim, J., Lee, S. H., Cho, M., Lee, J. Y., Choi, D. H., Lee, H. Y., Cho, S., Min, K. J., & Suh, Y. (2020). Small Molecule from Natural Phytochemical Mimics Dietary Restriction by Modulating FoxO3a and Metabolic Reprogramming. Advanced biosystems, 4(7), e1900248. https://doi.org/10.1002/adbi.201900248

    • Wei, S., Kohl, E., Djandji, A., Morgan, S., Whittier, S., Mansukhani, M., Hod, E., D'Alton, M., Suh, Y., & Williams, Z. (2020). Direct diagnostic testing of SARS-CoV-2 without the need for prior RNA extraction. medRxiv : the preprint server for health sciences, 2020.05.28.20115220. https://doi.org/10.1101/2020.05.28.20115220

    • Wei, S., Kohl, E., Djandji, A., Morgan, S., Whittier, S., Mansukhani, M., Yeh, R., Alejaldre, J. C., Fleck, E., D'Alton, M., Suh, Y., & Williams, Z. (2020). Field-deployable, rapid diagnostic testing of saliva samples for SARS-CoV-2. medRxiv : the preprint server for health sciences, 2020.06.13.20129841. https://doi.org/10.1101/2020.06.13.20129841

    • Lau, C. H., Tin, C., & Suh, Y. (2020). CRISPR-based strategies for targeted transgene knock-in and gene correction. Faculty reviews, 9, 20. https://doi.org/10.12703/r/9-20

    • Zhang, Z. D., Milman, S., Lin, J. R., Wierbowski, S., Yu, H., Barzilai, N., Gorbunova, V., Ladiges, W. C., Niedernhofer, L. J., Suh, Y., Robbins, P. D., & Vijg, J. (2020). Genetics of extreme human longevity to guide drug discovery for healthy ageing. Nature metabolism, 2(8), 663–672. https://doi.org/10.1038/s42255-020-0247-0

    • Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., de Cabo, R., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J., Gorbunova, V., de Grey, A., He, W. W., Hoeijmakers, J., Hoffman, E., Horvath, S., Houtkooper, R. H., Jensen, M. K., Jensen, M. B., Kane, A., Kassem, M., de Keizer, P., Kennedy, B., Karsenty, G., Lamming, D. W., Lee, K. F., MacAuley, N., Mamoshina, P., Mellon, J., Molenaars, M., Moskalev, A., Mund, A., Niedernhofer, L., Osborne, B., Pak, H. H., Parkhitko, A., Raimundo, N., Rando, T. A., Rasmussen, L. J., Reis, C., Riedel, C. G., Franco-Romero, A., Schumacher, B., Sinclair, D. A., Suh, Y., Taub, P. R., Toiber, D., Treebak, J. T., Valenzano, D. R., Verdin, E., Vijg, J., Young, S., Zhang, L., Bakula, D., Zhavoronkov, A., Scheibye-Knudsen, M. (2020). ARDD 2020: from aging mechanisms to interventions. Aging, 12(24), 24484–24503. https://doi.org/10.18632/aging.202454

    • Zhu, Y., & Suh, Y. (2020). Ultrafine mapping of chromosome conformation at hundred basepair resolution reveals regulatory genome architecture. bioRxiv, 743005.

    • Tombline, G., Gigas, J., Simon, M., Suh, Y., Seluanov, A., & Gorbunova, V. (2020). Omics of Long-Lived Mammals and Links to Human Centenarians. Innovation in Aging, 4(Suppl 1), 852.

    • Zeng, L., Yang, J., Peng, S., Zhu, J., Zhang, B., Suh, Y., & Tu, Z. (2020). Transcriptome analysis reveals the difference between “healthy” and “common” aging and their connection with age‐related diseases. Aging Cell, 19(3), e13121.

    • Shin, Y. J., Kwon, E. S., Lee, S. M., Kim, S. K., Min, K. W., Lim, J. Y., Lee, B., Kang, J.S., Kwak, J. Y., Son, Y. H., Choi, J. Y., Yang, Y. R., Kim, S., Kim, Y., Jang, H. C., Suh, Y., Yoon, J., Lee, K., & Kwon, K. S. (2020). A subset of microRNAs in the Dlk1‐Dio3 cluster regulates age‐associated muscle atrophy by targeting Atrogin‐1. Journal of cachexia, sarcopenia and muscle, 11(5), 1336-1350.

    • Chai, J. C., Deik, A. A., Hua, S., Wang, T., Hanna, D. B., Xue, X., Haberlen, S. A., Shah, S. J., Suh, Y., Lazar, J. M., Gustafson, D., Hodis, H. N., Landay, A. L., Anastos, K., Post, W. S., Kaplan, R. C., Clish, C. B., & Qi, Q. (2019). Association of Lipidomic Profiles With Progression of Carotid Artery Atherosclerosis in HIV Infection. JAMA cardiology, 4(12), 1239–1249. https://doi.org/10.1001/jamacardio.2019.4025

    • Johnson, S. C., Martinez, F., Bitto, A., Gonzalez, B., Tazaerslan, C., Cohen, C., Delaval, L., Timsit, J., Knebelmann, B., Terzi, F., Mahal, T., Zhu, Y., Morgan, P. G., Sedensky, M. M., Kaeberlein, M., Legendre, C., Suh, Y., & Canaud, G. (2019). mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases. Kidney international, 95(2), 455–466. https://doi.org/10.1016/j.kint.2018.08.038

    • Jung, H. J., Lee, K. P., Kwon, K. S., & Suh, Y. (2019). MicroRNAs in Skeletal Muscle Aging: Current Issues and Perspectives. The journals of gerontology. Series A, Biological sciences and medical sciences, 74(7), 1008–1014. https://doi.org/10.1093/gerona/gly207

    • Zhang, L., Yousefzadeh, M. J., Suh, Y., Niedernhofer, L. J., & Robbins, P. D. (2019). Signal Transduction, Ageing and Disease. Sub-cellular biochemistry, 91, 227–247. https://doi.org/10.1007/978-981-13-3681-2_9

    • Spivack, S., Dong, X., Shi, M. K., Han, W., Keller, S., Maslov, A., Suh, Y., & Vijg, J. (2019). MA04. 06 Lung Epithelium Whole Transcriptome Signatures That Reflect Incident Lung Cancer Case-Control Status. Journal of Thoracic Oncology, 14(10), S262.

    • Feintuch, C. M., Tare, A., Cusumano, L. R., Benayoun, J., Ryu, S., Sixpence, A., Seydel, K., Laufer, M., Taylor, T., Suh, Y., & Daily, J. P. (2018). Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi. The American journal of tropical medicine and hygiene, 98(6), 1692–1698. https://doi.org/10.4269/ajtmh.17-0887

    • Dong, X., Shi, M., Lee, M., Toro, R., Gravina, S., Han, W., Yasuda, S., Wang, T., Zhang, Z., Vijg, J., Suh, Y., & Spivack, S. D. (2018). Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung. Epigenetics, 13(3), 264–274. https://doi.org/10.1080/15592294.2018.1441650

    • Ryu, S., Han, J., Norden-Krichmar, T. M., Schork, N. J., & Suh, Y. (2018). Effective discovery of rare variants by pooled target capture sequencing: A comparative analysis with individually indexed target capture sequencing. Mutation research, 809, 24–31. https://doi.org/10.1016/j.mrfmmm.2018.03.007

    • Lau, C. H., & Suh, Y. (2018). CRISPR-based strategies for studying regulatory elements and chromatin structure in mammalian gene control. Mammalian genome : official journal of the International Mammalian Genome Society, 29(3-4), 205–228. https://doi.org/10.1007/s00335-017-9727-2

    • Lau, C. H., & Suh, Y. (2018). In vivo epigenome editing and transcriptional modulation using CRISPR technology. Transgenic research, 27(6), 489–509. https://doi.org/10.1007/s11248-018-0096-8

    • Yang, J., Zhang, B., Houten, S., Schadt, E., Zhu, J., Suh, Y., & Tu, Z. (2018). A novel approach of human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases. BioRxiv, 326264.

    • Shin, Y. J., Lee, S. M., Lim, J. Y., Lee, B., Jang, H. C., Suh, Y., Lee, K. P., & Kwon, K. S. (2018). The Dlk1-Dio3 miRNA cluster plays a crucial role in preventing muscle aging via targeting Atrogin-1. 한국장기요양학회 추계학술대회자료집, 2018, 195-195.

    • Hudgins, A. D., Tazearslan, C., Tare, A., Zhu, Y., Huffman, D., & Suh, Y. (2018). Age-and tissue-specific expression of senescence biomarkers in mice. Frontiers in genetics, 9, 59.

    • Hudgins, A. D., & Suh, Y. (2018). O4‐01‐03: FUNCTIONAL NON‐CODING VARIANTS AFFECTING ALZHEIMER'S DISEASE RISK IDENTIFIED BY MASSIVELY PARALLEL REPORTER ASSAY. Alzheimer's & Dementia, 14(7S_Part_26), P1400-P1401.

    • Jung, H. J., Lee, K. P., Milholland, B., Shin, Y. J., Kang, J. S., Kwon, K. S., & Suh, Y. (2017). Comprehensive miRNA Profiling of Skeletal Muscle and Serum in Induced and Normal Mouse Muscle Atrophy During Aging. The journals of gerontology. Series A, Biological sciences and medical sciences, 72(11), 1483–1491. https://doi.org/10.1093/gerona/glx025

    • Johnson, S. C., Gonzalez, B., Zhang, Q., Milholland, B., Zhang, Z., & Suh, Y. (2017). Network analysis of mitonuclear GWAS reveals functional networks and tissue expression profiles of disease-associated genes. Human genetics, 136(1), 55–65. https://doi.org/10.1007/s00439-016-1736-9

    • Zhu, Y., Tazearslan, C., & Suh, Y. (2017). Challenges and progress in interpretation of non-coding genetic variants associated with human disease. Experimental biology and medicine (Maywood, N.J.), 242(13), 1325–1334. https://doi.org/10.1177/1535370217713750

    • Milholland, B., Dong, X., Zhang, L., Hao, X., Suh, Y., & Vijg, J. (2017). Differences between germline and somatic mutation rates in humans and mice. Nature communications, 8, 15183. https://doi.org/10.1038/ncomms15183

    • Lau, C. H., & Suh, Y. (2017). In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease. F1000Research, 6, 2153. https://doi.org/10.12688/f1000research.11243.1

    • Hackl, M., Suh, Y., & Grillari, J. (2017). Editorial: Non-coding RNA in aging and age-associated diseases - from intracellular regulators to hormone like actions. Mechanisms of ageing and development, 168, 1–2. https://doi.org/10.1016/j.mad.2017.11.014

    • Lau, C. H., & Suh, Y. (2017). Genome and Epigenome Editing in Mechanistic Studies of Human Aging and Aging-Related Disease. Gerontology, 63(2), 103–117. https://doi.org/10.1159/000452972

    • Olivieri, F., Capri, M., Bonafè, M., Morsiani, C., Jung, H. J., Spazzafumo, L., Viña, J., & Suh, Y. (2017). Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging. Mechanisms of ageing and development, 165(Pt B), 162–170. https://doi.org/10.1016/j.mad.2016.12.004

    • Milholland, B., Suh, Y., & Vijg, J. (2017). Mutation and catastrophe in the aging genome. Experimental gerontology, 94, 34–40. https://doi.org/10.1016/j.exger.2017.02.073

    • Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., Grey, A. D., Dixit, V. D., Debonneuil, E., Dobrovolskaya, E., Fedichev, P., Fedintsev, A., Fraifeld, V., Franceschi, C., Freer, R., Fülöp, T., Feige, J., Gems, D., Gladyshev, V., Gorbunova, V., Irincheeva, I., Jager, S., Jazwinski, S. M., Kaeberlein, M., Kennedy, B., Khaltourina, D., Kovalchuk, I., Kovalchuk, O., Kozin, S., Kulminski, A., Lashmanova, E., Lezhnina, K., Liu, G. H., Longo, V., Mamoshina, P., Maslov, A., Magalhaes, J. P. D., Mitchell, J., Mitnitski, A., Nikolsky, Y., Ozerov, I., Pasyukova, E., Peregudova, D., Popov, V., Proshkina, E., Putin, E., Rogaev, E., Rogina, B., Schastnaya, J., Seluanov, A., Shaposhnikov, M., Simm, A., Skulachev, V., Skulachev, M., Solovev, I., Spindler, S., Stefanova, N., Suh, Y., Swick, A., Tower, J., Gudkov, A., Vijg, J., Voronkov, A., West, M., Wagner, W., Yashin, A., Zemskaya, N., Zhumadilov, Z., & Zhavoronkov, A. (2017). A review of the biomedical innovations for healthy longevity. Aging (Albany NY), 9(1), 7.

    • Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S. I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G. P., Chanock, S., Chen, M. H., Chen, T. C., Chen, Y. D. I., Chung, J., Miglianico, F. D. G., Eriksson, J., Ferrucci, L., Friedrich, N., Gnewuch, C., Goodarzi, M. O., Grarup, N., Guo, T., Hammer, E., Hayes, R. B., Hicks, A. A., Hofman, A., Houwing-Duistermaat, J. J., Hu, F., Hunter, D. J., Husemoen, L. L., Isaacs, A., Jacobs, K. B., Janssen, J. A. M. J. L., Jansson, J. O., Jehmlich, N., Johnson, S., Juul, A., Karlsson, M., Kilpelainen, T. O., Kovacs, P., Kraft, P., Li, C., Linneberg, A., Liu, Y., Loos, R. J. F., Lorentzon, M., Lu, Y., Maggio, M., Magi, R., Meigs, J., Mellstrom, D., Nauck, M., Newman, A. B., Pollak, M. N., Pramstaller, P. P., Prokopenko, I., Psaty, B. M., Reincke, M., Rimm, E. B., Rotter, J. I., Pierre, A. S., Schurmann, C., Seshadri, S., Sjogren, K., Slagboom, P. E., Strickler, H. D., Stumvoll, M., Suh, Y., Sun, Q., Zhang, C., Svensson, J., Tanaka, T., Tare, A., Toenjes, A., Uh, H. W., Duijn, C. M. V., Heemst, D. V., Vandenput, L., Vasan, R. S., Voelker, U., Willems, S. M., Ohlsson, C., Wallaschofski, H., & Kaplan, R. C. (2017). Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016)[erratum]. Aging Cell, 16(4), 898-898.

    • Hackl, M., Suh, Y., & Grillari, J. (2017). Non-coding RNA in aging and age-associated diseases-from intracellular regulators to hormone like actions. Mechanisms of ageing and development, 168, 1-2.

    • Ryu, S., Atzmon, G., Barzilai, N., Raghavachari, N., & Suh, Y. (2016). Genetic landscape of APOE in human longevity revealed by high-throughput sequencing. Mechanisms of ageing and development, 155, 7–9. https://doi.org/10.1016/j.mad.2016.02.010

    • Cho, M., & Suh, Y. (2016). Genetics of human aging. In Handbook of the Biology of Aging (pp. 327-358). Academic Press.

    • Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S. I., Bidlingmaier, M., Broer, L., CHARGE Longevity Working Group, Cappola, A., Ceda, G. P., Chanock, S., Chen, M. H., Chen, T. C., Chen, Y. D. I., Chung, J., Miglianico, F. D. G., Eriksson, J., Ferrucci, L., Friedrich, N., Gnewuch, C., Goodarzi, M. O., Grarup, N., Guo, T., Hammer, E., Hayes, R. B., Hicks, A. A., Hofman, A., Houwing-Duistermaat, J. J., Hu, F., Hunter, D. J., Husemoen, L. L., Isaacs, A., Jacobs, K. B., Janssen, J. A. M. J. L., Jansson, J. O., Jehmlich, N., Johnson, S., Juul, A., Karlsson, M., Kilpelainen, T. O., Kovacs, P., Kraft, P., Li, C., Linneberg, A., Liu, Y., Loos, R. J. F., Body Composition Genetics Consortium; Lorentzon, M., Lu, Y., Maggio, M., Magi, R., Meigs, J., Mellstrom, D., Nauck, M., Newman, A. B., Pollack, M. N., Pramstaller, P. P., Prokopenko, I., Psaty, B. M., Reincke, M., Rimm, E. B., Rotter, J. I., Pierre, A. S., Schurmann, C., Seshadri, S., Sjogren, K., Slagboom, P. E., Strickler, H. D., Stumvoll, M., Suh, Y., Sun, Q., Zhang, C., Svensson, J., Tanaka, T., Tare, A., Tonjes, A., Uh, H. W., Duijn, C. M. V., Heemst, D. V., Vandenput, L., Vasan, R. S., Volker, U., Willems, S. M., Ohlsson, C., Wallaschofski, H.s & Kaplan, R. C. (2016). Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits. Aging cell, 15(5), 811-824.

    • Xiong, X.-dong, Jung, H. J., Gombar, S., Park, J. Y., Zhang, C.-long, Zheng, H., Ruan, J., Li, J.-bin, Kaeberlein, M., Kennedy, B. K., Zhou, Z., Liu, X., & Suh, Y. (2015). MicroRNA transcriptome analysis identifies mir-365 as a novel negative regulator of cell proliferation in ZMPSTE24 -deficient mouse embryonic fibroblasts. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 777, 69–78. https://doi.org/10.1016/j.mrfmmm.2015.04.010

    • Han, J., Atzmon, G., Barzilai, N., & Suh, Y. (2015). Genetic variation in Sirtuin 1 (SIRT1) is associated with lipid profiles but not with longevity in Ashkenazi Jews. Translational research : the journal of laboratory and clinical medicine, 165(4), 480–481. https://doi.org/10.1016/j.trsl.2014.09.008

    • Cheng, J., Cho, M., Cen, J. M., Cai, M. Y., Xu, S., Ma, Z. W., Liu, X., Yang, X. L., Chen, C., Suh, Y., & Xiong, X. D. (2015). A TagSNP in SIRT1 gene confers susceptibility to myocardial infarction in a Chinese Han population. PloS one, 10(2), e0115339. https://doi.org/10.1371/journal.pone.0115339

    • Cho, S., Cho, M., Kim, J., Kaeberlein, M., Lee, S. J., & Suh, Y. (2015). Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism. Oncotarget, 6(1), 43–55. https://doi.org/10.18632/oncotarget.2723

    • McCormick, M. A., Delaney, J. R., Tsuchiya, M., Tsuchiyama, S., Shemorry, A., Sim, S., Chou, A. C., Ahmed, U., Carr, D., Murakami, C. J., Schleit, J., Sutphin, G. L., Wasko, B. M., Bennett, C. F., Wang, A. M., Olsen, B., Beyer, R. P., Bammler, T. K., Prunkard, D., Johnson, S. C., Pennypacker, J. K., An, E., Anies, A., Castanza, A. S., Choi, E., Dang, N., Enerio, S., Fletcher, M., Fox, L., Goswami, S., Higgins, S. A., Holmberg, M. A., Hu, D., Hui, J., Jelic, M., Jeong, K. S., Johnston, E., O Kerr, E., Kim, J., Kim, D., Kirkland, K., Klum, S., Kotireddy, S., Liao, E., Lim, M., Lin, M. S., Lo, W. C., Lockshon, D., Miller, H. A., Moller, R. M., Muller, B., Oakes, J., Pak, D. N., Peng, Z. J., Pham, K. M., Pollard, T. G., Pradeep, P., Pruett, D., Rai, D., Robison, B., Rodriguez, A. A., Ros, B., Sage, M., Singh, M. K., Smith, E. D., Snead, K., Solanky, A., Spector, B. L., Steffen, K. K., Tchao, B. N., Ting, M. K., Wende, H. V., Wang, D., Welton, K. L., Westman, E. A., Brem, R. B., Liu, X. G., Suh, Y., Zhou, Z., Kaeberlein, M., Kennedy, B. K. (2015). A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell metabolism, 22(5), 895–906. https://doi.org/10.1016/j.cmet.2015.09.008

    • Johnson, S. C., Yanos, M. E., Bitto, A., Castanza, A., Gagnidze, A., Gonzalez, B., Gupta, K., Hui, J., Jarvie, C., Johnson, B. M., Letexier, N., McCanta, L., Sangesland, M., Tamis, O., Uhde, L., Van Den Ende, A., Rabinovitch, P. S., Suh, Y., & Kaeberlein, M. (2015). Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice. Frontiers in genetics, 6, 247. https://doi.org/10.3389/fgene.2015.00247

    • Cui, H. J., Liu, X. G., McCormick, M., Wasko, B. M., Zhao, W., He, X., Yuan, Y., Fang, B. X., Sun, X. R., Kennedy, B. K., Suh, Y., Zhou, Z. J., Kaeberlein, M., & Feng, W. L. (2015). PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae. Age (Dordrecht, Netherlands), 37(3), 9788. https://doi.org/10.1007/s11357-015-9788-7

    • Ho, G., Jung, H. J., Schoen, R. E., Wang, T., Lin, J., Williams, Z., Weissfeld, J. L., Park, J. Y., Loudig, O., & Suh, Y. (2015). Differential expression of circulating microRNAs according to severity of colorectal neoplasia. Translational research : the journal of laboratory and clinical medicine, 166(3), 225–232. https://doi.org/10.1016/j.trsl.2015.02.004

    • MacRae, S. L., Zhang, Q., Lemetre, C., Seim, I., Calder, R. B., Hoeijmakers, J., Suh, Y., Gladyshev, V. N., Seluanov, A., Gorbunova, V., Vijg, J., & Zhang, Z. D. (2015). Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging cell, 14(2), 288–291. https://doi.org/10.1111/acel.12314

    • Wang, J., Telese, F., Tan, Y., Li, W., Jin, C., He, X., Basnet, H., Ma, Q., Merkurjev, D., Zhu, X., Liu, Z., Zhang, J., Ohgi, K., Taylor, H., White, R. R., Tazearslan, C., Suh, Y., Macfarlan, T. S., Pfaff, S. L., & Rosenfeld, M. G. (2015). LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control. Nature neuroscience, 18(9), 1256–1264. https://doi.org/10.1038/nn.4069

    • Park, C., Suh, Y., & Cuervo, A. M. (2015). Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage. Nature communications, 6, 6823. https://doi.org/10.1038/ncomms7823

    • Ryu, S., Teles, F., Minopoli, G., Russo, T., Rosenfeld, M. G., & Suh, Y. (2015). An epigenomic role of Fe65 in the cellular response to DNA damage. Mutation research, 776, 40–47. https://doi.org/10.1016/j.mrfmmm.2015.01.006

    • Johnson, S. C., Dong, X., Vijg, J., & Suh, Y. (2015). Genetic evidence for common pathways in human age-related diseases. Aging cell, 14(5), 809–817. https://doi.org/10.1111/acel.12362

    • Milholland, B., Gombar, S., & Suh, Y. (2015). SMiRK: an Automated Pipeline for miRNA Analysis. Source journal of genomics, 1(1), http://www.researchsource.org/journals/getarchivedata/5/36/SMiRK:-an-Automated-Pipeline-for-miRNA-Analysis.

    • Milholland, B., Auton, A., Suh, Y., & Vijg, J. (2015). Age-related somatic mutations in the cancer genome. Oncotarget, 6(28), 24627–24635. https://doi.org/10.18632/oncotarget.5685

    • Jung, H. J., & Suh, Y. (2015). Regulation of IGF -1 signaling by microRNAs. Frontiers in genetics, 5, 472. https://doi.org/10.3389/fgene.2014.00472

    • Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown-Borg, H. M., Caruso, C., Curiel, T. J., de Cabo, R., Franceschi, C., Gems, D., Ingram, D. K., Johnson, T. E., Kennedy, B. K., Kenyon, C., Klein, S., Kopchick, J. J., Lepperdinger, G., Madeo, F., Mirisola, M. G., Mitchell, J. R., Passarino, G., Rudolph, K. L., Sedivy, J. M., Shadel, G. S., Sinclair, D. A., Spindler, S. R., Suh, Y., Vijg, J., Vinciguerra, M., Fontana, L. (2015). Interventions to Slow Aging in Humans: Are We Ready?. Aging cell, 14(4), 497–510. https://doi.org/10.1111/acel.12338

    • Fontana, L., Antebi, A., Bartke, A., Barzilai, N., Brown-Borg, H., Curiel, T., Cabo, R. D., Franceschi, C., Gems, D., Ingram, D. K., Johnson, T. E. Kennedy, B. K., Kenyon, C., Klein, S., Kopchick, J. J., Lepperdinger, G., Madeo, F., Mirisola, M. G., Mitchell, J. R., Passarino, G., Rudolph, K. L., Sedivy, J. M., Shadel, G. S., Sinclair, D. A., Spindler, S. R., Suh, Y., Vijg, J., Vinciguerra, M., & Longo, V. D. (2015). Interventions to slow aging in humans: are we ready?[forthcoming]. Aging Cell.

    • Jung, H. J., & Suh, Y. (2015). Regulation of IGF-1 signaling by microRNAs. Frontiers in genetics, 5, 472.

    • Han, J., Atzmon, G., Barzilai, N., & Suh, Y. (2015). Genetic variation in SIRT1 is associated with lipid profiles but not with longevity in Ashkenazi Jews. Translational research: the journal of laboratory and clinical medicine, 165(4), 480.

    • Xiong, X. D., Jung, H. J., Gombar, S., Park, J. Y., Zhang, C. L., Zheng, H., Ruan, J., Li, J. B., Kaeberlein, M., Kennedy, B. K., Zhou, Z., Liu, X., & Suh, Y. (2015). MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 777, 69-78.

    • Johnson, S. C., Dong, X., Vijg, J., & Suh, Y. (2015). Genetic evidence for common pathways in human age‐related diseases. Aging cell, 14(5), 809-817.

    • Xiong, X. D., Cho, M., Cai, X. P., Cheng, J., Jing, X., Cen, J. M., Liu, X., Yang, X. L., & Suh, Y. (2014). A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression. Mutation research, 761, 15–20. https://doi.org/10.1016/j.mrfmmm.2014.01.001

    • Zhao, W., Fang, B. X., Niu, Y. J., Liu, Y. N., Liu, B., Peng, Q., Li, J. B., Wasko, B. M., Delaney, J. R., Kennedy, B. K., Suh, Y., Zhou, Z. J., Kaeberlein, M., & Liu, X. G. (2014). Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. Mechanisms of ageing and development, 138, 53–58. https://doi.org/10.1016/j.mad.2014.01.007

    • Schneider, J. L., Suh, Y., & Cuervo, A. M. (2014). Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. Cell metabolism, 20(3), 417–432. https://doi.org/10.1016/j.cmet.2014.06.009

    • Jung, H. J., & Suh, Y. (2014). Circulating miRNAs in ageing and ageing-related diseases. Journal of genetics and genomics = Yi chuan xue bao, 41(9), 465–472. https://doi.org/10.1016/j.jgg.2014.07.003

    • Cho, M., & Suh, Y. (2014). Genome maintenance and human longevity. Current opinion in genetics & development, 26, 105–115. https://doi.org/10.1016/j.gde.2014.07.002

    • Garagnani, P., Giuliani, C., Pirazzini, C., Olivieri, F., Bacalini, M. G., Ostan, R., Mari, D., Passarino, G., Monti, D., Bonfigli, A. R., Boemi, M., Ceriello, A., Genovese, S., Sevini, F., Luiselli, D., Tieri, P., Capri, M., Salvioli, S., Vijg, J., Suh, Y., Delledone, M., Testa, R., Franceschi, C. (2013). Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes. Aging, 5(5), 373–385. https://doi.org/10.18632/aging.100562

    • Han, J., Ryu, S., Moskowitz, D. M., Rothenberg, D., Leahy, D. J., Atzmon, G., Barzilai, N., & Suh, Y. (2013). Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by Target Capture and next-generation sequencing. Mechanisms of Ageing and Development, 134(10), 478–485. https://doi.org/10.1016/j.mad.2013.01.005

    • Han, J., Hubbard, B. P., Lee, J., Montagna, C., Lee, H. W., Sinclair, D. A., & Suh, Y. (2013). Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. Cell cycle (Georgetown, Tex.), 12(2), 263–270. https://doi.org/10.4161/cc.23056

    • Cho, S. Y., Cho, M., Seo, D. B., Lee, S. J., & Suh, Y. (2013). Identification of a small molecule activator of SIRT1 gene expression. Aging, 5(3), 174–182. https://doi.org/10.18632/aging.100539

    • Vijg, J., & Suh, Y. (2013). Genome instability and aging. Annual review of physiology, 75, 645–668. https://doi.org/10.1146/annurev-physiol-030212-183715

    • Hasty, P., Suh, Y., & Vijg, J. (2013). Longevity Assurance by Genome Maintenance. DNA Repair and Cancer: From Bench to Clinic, 25.

    • Zhao, L., Yang, F., Xu, K., Cao, H., Zheng, G. Y., Zhang, Y., Li, J., Cui, H., Chen, X., Zhu, Z., He, H., Mo, X., Kennedy, B. K., Suh, Y., Zeng, Y., & Tian, X. L. (2012). Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging cell, 11(6), 1094–1101. https://doi.org/10.1111/acel.12011

    • Gombar, S., Jung, H. J., Dong, F., Calder, B., Atzmon, G., Barzilai, N., Tian, X. L., Pothof, J., Hoeijmakers, J. H., Campisi, J., Vijg, J., & Suh, Y. (2012). Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC genomics, 13, 353. https://doi.org/10.1186/1471-2164-13-353

    • Liu, B., Ghosh, S., Yang, X., Zheng, H., Liu, X., Wang, Z., Jin, G., Zheng, B., Kennedy, B. K., Suh, Y., Kaeberlein, M., Tryggvason, K., & Zhou, Z. (2012). Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell metabolism, 16(6), 738–750. https://doi.org/10.1016/j.cmet.2012.11.007

    • Tazearslan, C., Cho, M., & Suh, Y. (2012). Discovery of functional gene variants associated with human longevity: opportunities and challenges. The journals of gerontology. Series A, Biological sciences and medical sciences, 67(4), 376–383. https://doi.org/10.1093/gerona/glr200

    • Jung, H. J., & Suh, Y. (2012). MicroRNA in Aging: From Discovery to Biology. Current genomics, 13(7), 548–557. https://doi.org/10.2174/138920212803251436

    • Kim, M., Kim, C., Choi, Y. S., Kim, M., Park, C., & Suh, Y. (2012). Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: implication to age-associated bone diseases and defects. Mechanisms of ageing and development, 133(5), 215–225. https://doi.org/10.1016/j.mad.2012.03.014

    • Suh, Y., & Kennedy, B. K. (2012). Dialing down SUN1 for laminopathies. Cell, 149(3), 509–510. https://doi.org/10.1016/j.cell.2012.04.003

    • Gombar, S., Shi, M., Locker, J., Zhu, C., Keller, S., Suh, Y., & Spivack, S. (2012). Abstract B36: Micronome-wide explorations of NSCLC: microRNA-seq discovery. Clinical Cancer Research, 18(3 Supplement), B36-B36.

    • Kim, M., Kim, C., Choi, Y. S., Kim, M., Park, C., & Suh, Y. (2012). Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: implication to age-associated bone diseases and defects. Mechanisms of ageing and development, 133(5), 215-225.

    • Maslov, A. Y., Lee, M., Gundry, M., Gravina, S., Strogonova, N., Tazearslan, C., Bendebury, A., Suh, Y., & Vijg, J. (2012). 5-aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1. Oncogene, 31(50), 5172-5179.

    • Zhao, L., Yang, F., Xu, K., Cao, H., Zheng, G. Y., Zhang, Y., Li, J., Cui, H., Chen, X., Zhu, Z., He, H., Mo, X., Kennedy, B. K., Suh, Y., Zeng, Y., & Tian, X. L. (2012). Common genetic variants of the β2‐adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging cell, 11(6), 1094-1101.

    • Tazearslan, C., Huang, J., Barzilai, N., & Suh, Y. (2011). Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles. Aging cell, 10(3), 551–554. https://doi.org/10.1111/j.1474-9726.2011.00697.x

    • Choi, H. R., Cho, K. A., Kang, H. T., Lee, J. B., Kaeberlein, M., Suh, Y., Chung, I. K., & Park, S. C. (2011). Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix. Aging cell, 10(1), 148–157. https://doi.org/10.1111/j.1474-9726.2010.00654.x

    • Delaney, J. R., Sutphin, G. L., Dulken, B., Sim, S., Kim, J. R., Robison, B., Schleit, J., Murakami, C. J., Carr, D., An, E. H., Choi, E., Chou, A., Fletcher, M., Jelic, M., Liu, B., Lockshon, D., Moller, R. M., Pak, D. N., Peng, Q., Peng, Z. J., Pham, K. M., Sage, M., Solanky, A., Steffen, K. K., Tsuchiya, M., Tsuchiyama, S., Johnson, S., Raabe, C., Suh, Y., Zhou, Z., Liu, X., Kennedy, B. K., Kaeberlein, M. (2011). Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging cell, 10(6), 1089–1091. https://doi.org/10.1111/j.1474-9726.2011.00742.x

    • Kaeberlein, M., Kennedy, B. K., Liu, X., Suh, Y., & Zhou, Z. (2011). Trinations aging symposium. Mechanisms of ageing and development, 132(6-7), 348–352. https://doi.org/10.1016/j.mad.2011.07.001

    • Tazearslan, C., Huang, J., Barzilai, N., & Suh, Y. (2011). Impaired IGF1R signaling in cells expressing longevity‐associated human IGF1R alleles. Aging cell, 10(3), 551-554.

    • Shi, M., Gombar, S., Wang, T., Suh, Y., & Spivack, S. (2011, June). MICRORNA EXPRESSION PROFILES IN LUNG ADENOCARCINOMA TISSUES VERSUS ADJACENT LUNG TISSUES USING NEXT-GEN SEQUENCING. In JOURNAL OF THORACIC ONCOLOGY (Vol. 6, No. 6, pp. S1030-S1030). 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA: LIPPINCOTT WILLIAMS & WILKINS.Delaney, J. R., Sutphin, G. L., Dulken, B., Sim, S., Kim, J. R., Robison, B., Schleit, J., Murakami, C. J., Carr, D., An, E. H., Choi, E., Chou, A., Fletcher, M., Jelic, M., Liu, B., Lockshon, D., Moller, R. M., Pak, D. N., Peng, Q., Peng, Z. J., Pham, K. M., Sage, M., Solanky, A., Steffen, K. K., Tsuchiya, M., Tsuchiyama, S., Johnson, S., Raabe, c., Suh, Y., Zhou, Z., Liu, X., Kennedy, B. K., & Kaeberlein, M. (2011). Sir2 deletion prevents lifespan extension in 32 long‐lived mutants. Aging cell, 10(6), 1089-1091.

    • Oh, Y. S., Kim, D. G., Kim, G., Choi, E. C., Kennedy, B. K., Suh, Y., Park, B. J., & Kim, S. (2010). Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice. Aging cell, 9(5), 810–822. https://doi.org/10.1111/j.1474-9726.2010.00614.x

    • Suh, Y., & Vijg, J. (2010). The long and short of fertility and longevity. Cell metabolism, 12(3), 209–210. https://doi.org/10.1016/j.cmet.2010.08.009

    • Barzilai, N., Gabriely, I., Atzmon, G., Suh, Y., Rothenberg, D., & Bergman, A. (2010). Genetic studies reveal the role of the endocrine and metabolic systems in aging. The Journal of clinical endocrinology and metabolism, 95(10), 4493–4500. https://doi.org/10.1210/jc.2010-0859

    • Song, X., Cho, M., Han, J., Hazuda, H., Duggirala, R., Blangero, J., Rosenfeld, M. G., & Suh, Y. (2010). Molecular mechanisms of a disease susceptibility variant of SIRT1: Genotoxic stress‐induced, CTCF‐dependent activation of SIRT1 gene expression. The FASEB Journal, 24, 833-23.

    • Barzilai, N., Gabriely, I, Atzmon, G., Suh, Y., Rothenberg, D., & Bergman, A.. (2010). Genetic studies reveal the role of the endocrine and metabolic systems in aging. The Journal of Clinical Endocrinology & Metabolism, 95(10), 4493-4500.

    • Atzmon, G., Cho, M., Cawthon, R. M., Budagov, T., Katz, M., Yang, X., Siegel, G., Bergman, A., Huffman, D. M., Schechter, C. B., Wright, W. E., Shay, J. W., Barzilai, N., Govindaraju, D. R., & Suh, Y. (2009). Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proceedings of the National Academy of Sciences, 107(suppl_1), 1710–1717. https://doi.org/10.1073/pnas.0906191106

    • Busuttil, R. A., Muñoz, D. P., Garcia, A. M., Rodier, F., Kim, W. H., Suh, Y., Hasty, P., Campisi, J., & Vijg, J. (2008). Effect of ku80 deficiency on mutation frequencies and spectra at a lacz reporter locus in mouse tissues and cells. PLoS ONE, 3(10). https://doi.org/10.1371/journal.pone.0003458

    • Lee, J., Saha, P. K., Yang, Q.-H., Lee, S., Park, J. Y., Suh, Y., Lee, S.-K., Chan, L., Roeder, R. G., & Lee, J. W. (2008). Targeted inactivation of MLL3 histone H3–lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proceedings of the National Academy of Sciences, 105(49), 19229–19234. https://doi.org/10.1073/pnas.0810100105

    • Park, J. Y., Cho, M.-O., Leonard, S., Calder, B., Mian, I. S., Kim, W. H., Wijnhoven, S., van Steeg, H., Mitchell, J., van der Horst, G. T., Hoeijmakers, J., Cohen, P., Vijg, J., & Suh, Y. (2008). Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging XPDTTD MICE. PLoS ONE, 3(6). https://doi.org/10.1371/journal.pone.0002346

    • Suh, Y., Atzmon, G., Cho, M. O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., & Cohen, P. (2008). Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proceedings of the National Academy of Sciences of the United States of America, 105(9), 3438–3442. https://doi.org/10.1073/pnas.0705467105

    • Schumacher, B., van der Pluijm, I., Moorhouse, M. J., Kosteas, T., Robinson, A. R., Suh, Y., Breit, T. M., van Steeg, H., Niedernhofer, L. J., van Ijcken, W., Bartke, A., Spindler, S. R., Hoeijmakers, J. H., van der Horst, G. T., & Garinis, G. A. (2008). Delayed and accelerated aging share common longevity assurance mechanisms. PLoS genetics, 4(8), e1000161. https://doi.org/10.1371/journal.pgen.1000161

    • Vijg, J., Maslov, A. Y., & Suh, Y. (2008). Aging: a sirtuin shake-up?. Cell, 135(5), 797–798. https://doi.org/10.1016/j.cell.2008.11.008

    • Choi, B., Suh, Y., Kim, W. H., Christa, L., Park, J., & Bae, C. D. (2007). Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas. Experimental & molecular medicine, 39(6), 796–804. https://doi.org/10.1038/emm.2007.86

    • Choi, J. H., Ahn, B. M., Yi, J., Lee, J. H., Lee, J. H., Nam, S. W., Chon, C. Y., Han, K. H., Ahn, S. H., Jang, I. J., Cho, J. Y., Suh, Y., Cho, M. O., Lee, J. E., Kim, K. H., & Lee, M. G. (2007). MRP2 haplotypes confer differential susceptibility to toxic liver injury. Pharmacogenetics and genomics, 17(6), 403–415. https://doi.org/10.1097/01.fpc.0000236337.41799.b3

    • van de Ven, M., Andressoo, J. O., Holcomb, V. B., Hasty, P., Suh, Y., van Steeg, H., Garinis, G. A., Hoeijmakers, J. H., & Mitchell, J. R. (2007). Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging. Mechanisms of ageing and development, 128(1), 58–63. https://doi.org/10.1016/j.mad.2006.11.011

    • Vijg, J., & Suh, Y. (2007). Third International Conference on Functional Genomics of Ageing, March 29–April 1 2006, Palermo, Sicily, Italy. Mechanisms of Ageing and Development, 1(128), 3-4.

    • Choi, B., Suh, Y., Kim, W. H., Christa, L., Park, J., & Bae, C. D. (2007). Downregulation of regenerating islet-derived 3 α (REG3A) in primary human gastric adenocarcinomas. Experimental & molecular medicine, 39(6), 796-804.

    • Vijg, J., & Suh, Y. (2007). A Genetic Balancing Act. Annual Review of Gerontology and Geriatrics, Volume 27, 2007: Biopsychosocial Approaches to Longevity, 27, 11.

    • van de Ven, M., Andressoo, J.-O., Holcomb, V. B., von Lindern, M., Jong, W. M., De Zeeuw, C. I., Suh, Y., Hasty, P., Hoeijmakers, J. H., van der Horst, G. T., & Mitchell, J. R. (2006). Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice. PLoS Genetics, 2(12). https://doi.org/10.1371/journal.pgen.0020192

    • Suh, Y., & Vijg, J. (2006). Maintaining genetic integrity in aging: a zero sum game. Antioxidants & redox signaling, 8(3-4), 559–571. https://doi.org/10.1089/ars.2006.8.559

    • Vijg, J., & Suh, Y. (2006). Ageing: chromatin unbound. Nature, 440(7086), 874–875. https://doi.org/10.1038/440874a

    • Barzilail, N., Atzmon, G., Suh, Y., & Cohen, P. (2006). PL11 DISCOVERING THE SIMPLE AND COMPLEX GENETIC TRAITS FOR EXCEPTIONAL LONGEVITY. Growth Hormone & IGF Research, (16), S25-S26.

    • Lee, S. J., Kim, Y. D., Suh, Y., Lee, S. K., & Park, C. W. (2006). Morphological and chromosomal variation of the Dryopteris varia (L.) Kuntze complex (Dryopteridaceae) in Korea. Plant Systematics and Evolution, 262(1), 37-52.

    • Busuttil, R. A., Garcia, A. M., Cabrera, C., Rodriguez, A., Suh, Y., Kim, W. H., Huang, T.-T., & Vijg, J. (2005). Organ-specific increase in mutation accumulation and apoptosis rate in CUZN-superoxide dismutase–deficient mice. Cancer Research, 65(24), 11271–11275. https://doi.org/10.1158/0008-5472.can-05-2980

    • Suh, Y., & Cantor, C. (2005). Single nucleotide polymorphisms (SNPs): detection, interpretation, and application. Mutation research, 573(1-2), 1–2. https://doi.org/10.1016/j.mrfmmm.2005.01.003

    • Suh, Y., & Vijg, J. (2005). SNP discovery in associating genetic variation with human disease phenotypes. Mutation research, 573(1-2), 41–53. https://doi.org/10.1016/j.mrfmmm.2005.01.005

    • Vijg, J., & Suh, Y. (2005). Genetics of longevity and aging. Annual review of medicine, 56, 193–212. https://doi.org/10.1146/annurev.med.56.082103.104617

    • Cho, J. Y., Lim, H. S., Suh, Y. S., Chung, J. Y., Hong, K. S., Yi, S. Y., Yu, K. S., Jang, I. J., & Shin, S. G. (2005). Pharmacokinetics of rosiglitazone according to CYP2C8 genotype in Korean population. Journal of Korean Society for Clinical Pharmacology and Therapeutics, 13(2), 142-156.

    • Vijg, J., & Suh, Y. (2005). Second international conference on Functional Genomics of Ageing, April 28–May 1 2004, Hersonissos, Crete, Greece. Mechanisms of Ageing and Development, 1(126), 1-2.

    • Lee, J. H., Choi, J. H., Namkung, W., Hanrahan, J. W., Chang, J., Song, S. Y., Park, S. W., Kim, D. S., Yoon, J.-H., Suh, Y., Jang, I.-J., Nam, J. H., Kim, S. J., Cho, M.-O., Lee, J.-E., Kim, K. H., & Lee, M. G. (2003). A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases. Human Molecular Genetics, 12(18), 2321–2332. https://doi.org/10.1093/hmg/ddg243

    • Bae, C.-D., Sung, Y.-S., Jeon, S.-M., Suh, Y., Yang, H.-K., Kim, Y. I., Park, K.-H., Choi, J., Ahn, G., & Park, J. (2003). Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas. Journal of Cancer Research and Clinical Oncology, 129(11), 621–630. https://doi.org/10.1007/s00432-003-0484-0

    • Vijg, J., & Suh, Y. (2003). Functional genomics of ageing. Mechanisms of ageing and development, 124(1), 3–8. https://doi.org/10.1016/s0047-6374(02)00163-x

    • Vijg, J., & Suh, Y. (2003). International Conference on'Functional Genomics of Ageing', April 24-27, 2002, Seville, Spain. Mechanisms of Ageing and Development, 124(1), 1-1.

    • Bounpheng, M., McGrath, S., Macias, D., van Orsouw, N., Suh, Y., Rines, D., & Vijg, J. (2003). Rapid, inexpensive scanning for all possible BRCA1 and BRCA2 gene sequence variants in a single assay: implications for genetic testing. Journal of medical genetics, 40(4), e33-e33.

    • Lee, J. H., Choi, J. H., Namkung, W., Hanrahan, J. W., Chang, J., Song, S. Y., Park, S. W., Kim, D. S., Yoon, J. H., Suh, Y., Jang, I. J., Nam, J. H., Kim, S. J., Cho, M. O., Lee, J. E., Kim, K. H., & Lee, M. G. (2003). A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases. Human molecular genetics, 12(18), 2321-2332.

    • Vijg, J., & Suh, Y. (2003). Screening for mutations in cancer predisposition genes. Genetic predisposition to cancer. 2nd ed. London: Edward Arnold.

    • Bae, C. D., Sung, Y. S., Jeon, S. M., Suh, Y., Yang, H. K., Kim, Y. I., Park, K. H., Choi, J., Ahn, G., & Park, J. (2003). Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas. Journal of cancer research and clinical oncology, 129(11), 621-630.

    • Suh, Y., Lee, K. A., Kim, W. H., Han, B. G., Vijg, J., & Park, S. C. (2002). Aging alters the apoptotic response to genotoxic stress. Nature medicine, 8(1), 3–4. https://doi.org/10.1038/nm0102-3

    • Suh Y. (2002). Cell signaling in aging and apoptosis. Mechanisms of ageing and development, 123(8), 881–890. https://doi.org/10.1016/s0047-6374(02)00025-8

    • Suh, Y., Lee, K., Kim, W. H., Han, B. G., Vijg, J., & Park, S. C. (2002). Aging alters the apoptotic response to genotoxic stress. Nature medicine, 8(1), 3-4.

    • Cho, S. I., Suh, Y. S., Kim, H., Min, H. J., Cho, M. O., & Park, S. C. (2002). Association study with haplotypes of MLH1 gene. 대한예방의학회: 학술대회논문집, 431-431.

    • Suh, Y. (2002). Cell signaling in aging and apoptosis. Mechanisms of ageing and development, 123(8), 881-890.

    • Kim, D. J., Chung, J. H., Ryu, Y. S., Rhim, J. H., Kim, C. W., Suh, Y., & Chung, H. K. (2002). Production and characterisation of a recombinant scFv reactive with human gastrointestinal carcinomas. British journal of cancer, 87(4), 405-413.

    • Suh, Y. (2001). CSNP discovery by two-dimensional gene scanning (TDGS). Experimental & molecular medicine, 33(1 Suppl), 21-47.

    • Suh, Y., Kim, D. I., Park, J. S., Park, W. Y., & Park, S. C. (2001). Induction of Senescence‐like Phenotype by an Alkylating Agent, Methyl Methanesulfonante, in Human Diploid Fibroblast. Annals of the New York Academy of Sciences, 928(1), 365-365.

    • Kang, C. M., Suh, Y., Jang, I. S., & Park, S. (2001). Thymidine-dependent attenuation of the mitochondrial apoptotic pathway in adenosine-induced apoptosis of HL-60 cells. Journal of cancer research and clinical oncology, 127(9), 570-576.

    • Suh, Y. (2001). Age-specific changes in expression, activity, and activation of the c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in rats. Mechanisms of ageing and development, 122(15), 1797-1811.

    • Suh, Y., & Park, S. C. (2001). Differential activation of mitogen-activated protein kinases by methyl methanesulfonate in the kidney of young and old rats. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 497(1-2), 11-18.

    • McGrath, S. B., Bounpheng, M., Torres, L., Calavetta, M., Scott, C. B., Suh, Y., Rines, D., Orsouw, N. V., & Vijg, J. (2001). High-speed, multicolor fluorescent two-dimensional gene scanning. Genomics, 78(1-2), 83-90.

    • Suh, Y., Kang, U. G., Kim, Y. S., Kim, W. H., Park, S. C., & Park, J. B. (2000). Regular Articles-Carcinogenesis-Differential Activation of c-Jun NH2-terminal Kinase and p38 Mitogen-activated Protein Kinases by Methyl Methanesulfonate in the Liver and Brain of Rats. Cancer Research, 60(18), 5067-5073.

    • Suh, Y., Park, W. Y., & Park, S. C. (2000). The 8th Congress of the International Association of Biomedical Gerontology. Mechanisms of Ageing and Development, 1(116), 47-57.

    • Suh, Y., Kang, U. G., Kim, Y. S., Kim, W. H., Park, S. C., & Park, J. B. (2000). Differential activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in the liver and brain of rats: implication for organ-specific carcinogenesis. Cancer research, 60(18), 5067-5073.

    • Suh, Y., & Benedik, M. J. (1997). Secretion of nuclease across the outer membrane of serratia marcescens and its energy requirements. Journal of Bacteriology, 179(3), 677–683. https://doi.org/10.1128/jb.179.3.677-683.1997

    • Chen, Y.-chi, Suh, Y., Riise, E., Kartman, B., Jin, S., & Benedik, M. J. (1996). Inhibition of serratia marcescens nuclease secretion by a truncated nuclease peptide. Gene, 172(1), 9–16. https://doi.org/10.1016/0378-1119(96)00187-4

    • Suh, Y., Jin, S., Ball, T. K., & Benedik, M. J. (1996). Two step secretion of extracellular nuclease in Serratia marcescens. J. Bacteriol, 178(13), 3771-3778.

    • Suh, Y., Jin, S., Ball, T. K., & Benedik, M. J. (1996). Two-step secretion of the Serratia marcescens extracellular nuclease. Journal of Bacteriology, 178(13), 3771–3778. https://doi.org/10.1128/jb.178.13.3771-3778.1996

    • Suh, Y., Alpaugh, M., Krause, K. L., & Benedik, M. J. (1995). Differential secretion of isoforms of serratia marcescens extracellular nuclease. Applied and Environmental Microbiology, 61(11), 4083–4088. https://doi.org/10.1128/aem.61.11.4083-4088.1995

    • Suh, Y. (1994). Extracellular secretion of Serratia marcescens nuclease and metalloprotease (Doctoral dissertation, University of Houston).

    • Klebanov, S., Diais, S., Stavinoha, W., Suh, Y., & Nelson, J. F. (1993). Food restriction, elevated corticosterone, and attenuated inflammatory response to carrageen an in male BALB/C mice. Gerontologist, 33(Special Issue), 96.

    • Suh, Y., & Benedik, M. J. (1992). Production of active serratia marcescens metalloprotease from escherichia coli by alpha-hemolysin HlyB and hlyd. Journal of Bacteriology, 174(7), 2361–2366. https://doi.org/10.1128/jb.174.7.2361-2366.1992

    • Ball, T. K., Suh, Y., & Benedik, M. J. (1992). Disulfide bonds are required for Serratia marcescens nuclease activity. Nucleic Acids Research, 20(19), 4971–4974. https://doi.org/10.1093/nar/20.19.4971Zhang, Y., Conway, C., Rosato, M., Suh, Y., & Manson, M. D. (1992). Maltose chemotaxis involves residues in the N-terminal and C-terminal domains on the same face of maltose-binding protein. Journal of Biological Chemistry, 267(32), 22813–22820. https://doi.org/10.1016/s0021-9258(18)50020-x